Thorn BioScience LLC is focused on controlled
release animal pharmaceuticals through two delivery systems developed
with Southern Research Institute (SRI) and Southern
BioSystems (SBS).
The
delivery system utilizes sucrose
acetate isobutyrate (SAIB), a fully esterified sucrose molecule
which is a highly viscous, resin-like material in pure form. The addition
of small amounts of organic solvents to SAIB greatly reduces its viscosity
to an injectable consistency for drug delivery.
Once injected, the
organic solvent dissipates into the tissues leaving behind a SAIB/
drug delivery matrix which releases drug by diffusion. SAIB has
been used to deliver actives for periods of up to one month. It is degraded
by enzymatic hydrolysis into sucrose and its aliphatic acids. In
addition, SAIB has bio-adhesive qualities which have been utilized
to deliver therapeutics topically and to deliver antigens
on mucosal surfaces.
Current areas of research in product development
by TBS using SAIB include ovulation
induction products, vaccines, and antibiotic, anti-inflammatory
and peptide delivery.
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